Ergotamines in migraine headache treatment
Ergotamine-containing drugs, such as Cafergot®, have a long history of use in migraine headache treatment . Ergotamine also binds to serotonin receptor sites in the blood vessels, causing constriction. Some experts suggest that ergot drugs should be given as a rectal suppository, because absorption is better.
Ergotamine-containing drugs are available by prescription only. Frequent use can cause rebound headaches, and side effects can include upset stomach or vomiting.
Triptans are available in the US by prescription only and are substantially more expensive than either over-the-counter medications or ergot drugs. Frequent use of triptans can also cause rebound headaches, and side effects can include flushing of the face, tingling, dizziness, or a sudden feeling of warmth